Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 19/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 19/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4309433 | 0.95 | ALDH1A1 (0.41) | KEAP1NFE2L2BCHECNR2 | |
| SCHEMBL3927338 | 0.84 | KEAP1 (0.49) | KEAP1NFE2L2 | |
| SCHEMBL3922237 | 0.80 | ALDH1A1 (0.46) | KEAP1NFE2L2 | |
| SCHEMBL648387 | 0.78 | KEAP1 (0.48) | KEAP1NFE2L2 | |
| SCHEMBL3916604 | 0.77 | KDM4E (0.40) | KEAP1NFE2L2 | |
| SCHEMBL646673 | 0.75 | CA12 (0.43) | KEAP1NFE2L2 | |
| SCHEMBL3920448 | 0.73 | KEAP1 (0.44) | KEAP1NFE2L2 | |
| SCHEMBL4957519 | 0.72 | ALDH1A1 (0.47) | KEAP1NFE2L2 | |
| SCHEMBL28710605 | 0.72 | KEAP1 (0.46) | KEAP1NFE2L2 | |
| SCHEMBL3916606 | 0.70 | KDM4E (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038267-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | Novartis AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| WO-2007115058-A2 | THIADIAZOLIDINONE INHIBITORS OF PTPASE | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |