Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777683 | 0.92 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL1973194 | 0.88 | GAA (0.50) | SMN1; SMN2ALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL1001879 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAMAPTALDH1A1KMT2A | |
| SCHEMBL13510871 | 0.78 | GAA (0.52) | SMN1; SMN2ALDH1A1NPC1KMT2AMEN1 | |
| SCHEMBL19033759 | 0.77 | CYP2C19 (0.54) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL4400570 | 0.77 | CTSB (0.56) | SMN1; SMN2LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL14273893 | 0.77 | HDAC1 (0.51) | LMNAALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL3662863 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL7652554 | 0.75 | NPC1 (0.58) | SMN1; SMN2LMNAMAPTALDH1A1NPC1 | |
| SCHEMBL3491340 | 0.75 | NAMPT (0.46) | SMN1; SMN2LMNAMAPTTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029592-A1 | PHARMACEUTICAL COMPOUNDS | Astex Therapeutics Limited (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007125325-A1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |