Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10709727 | 0.82 | POLB (0.49) | KMT2ACTSK | |
| SCHEMBL8757522 | 0.81 | GLA (0.67) | SMN1; SMN2KMT2AGLAALDH1A1LMNA | |
| SCHEMBL1403874 | 0.80 | CTSB (0.50) | KMT2AFAAHTRPV1CTSK | |
| SCHEMBL3919908 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2KMT2AALDH1A1LMNANPC1 | |
| SCHEMBL2777683 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2KMT2AALDH1A1LMNANPSR1 | |
| SCHEMBL2051405 | 0.75 | CTSL (0.35) | KMT2AFAAHGAAMEN1 | |
| SCHEMBL8019170 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AGLAALDH1A1LMNA | |
| SCHEMBL31697584 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2KMT2AGLAALDH1A1LMNA | |
| SCHEMBL32687673 | 0.74 | ANPEP (0.43) | SMN1; SMN2KMT2AALDH1A1LMNANPC1 | |
| SCHEMBL21218528 | 0.74 | GHSR (0.35) | KMT2AALDH1A1FAAHTRPV1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234983-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | Wyeth LLC (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079630-A1 | 4-IMIDAZOLIDINONES AS KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2009-06-25 | — | — | WO | disclosed |