Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 11/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217907 | 0.84 | DPP4 (0.43) | DPP4DPP8KMOGPR119VNN1 | |
| SCHEMBL3922240 | 0.70 | DPP4 (0.34) | DPP4DPP8 | |
| SCHEMBL8221580 | 0.70 | DPP4 (0.43) | DPP4DPP8GPR119VNN1ITGAL | |
| SCHEMBL3930048 | 0.70 | DPP4 (0.32) | DPP4DPP8 | |
| SCHEMBL13472397 | 0.68 | KMO (0.56) | KMOGPR119 | |
| SCHEMBL13474216 | 0.68 | KMO (0.73) | KMO | |
| SCHEMBL13472393 | 0.67 | MAP4K4 (0.52) | KMOITGAL | |
| SCHEMBL13940552 | 0.67 | MAP4K4 (0.52) | KMOITGAL | |
| SCHEMBL3929559 | 0.66 | DPP4 (0.66) | DPP4DPP8GPR119ITGAL | |
| SCHEMBL12168416 | 0.66 | KMO (0.71) | KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485641-B2 | Substituted 3-amino-pyrrolidino-4-lactams | PFIZER, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20070299076-A1 | Substituted 3-Amino-Pyrrolidino-4-Lactams | PFIZER INC | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299076-A1 | Substituted 3-Amino-Pyrrolidino-4-Lactams | PRMT1, PRMT7, PRMT3 | DPP4 783/4885DPP8 1978/4885KMO 1958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.