SCHEMBL3921085

SCHEMBL3921085

Cc1cccc(CC(C)C(N)=O)c1C

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.40
KCNH2 Q12809 1/20 0.40
NR3C1 P04150 1/20 0.39
PGR P06401 1/20 0.39
NR3C2 P08235 1/20 0.39
ESR2 Q92731 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
HSD17B10 Q99714 1/20 0.38
GABRA1 P14867 1/20 0.36
GABRB2 P47870 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL363390 0.86 PPARG (0.43) ALDH1A1
SCHEMBL24899379 0.84 L3MBTL1 (0.46) ESR1KCNH2NR3C1PGRNR3C2
SCHEMBL430339 0.84 L3MBTL1 (0.46) ESR1KCNH2NR3C1PGRNR3C2
SCHEMBL28310658 0.83 NOS3 (0.42) ESR1KCNH2NR3C1PGRNR3C2
Acetic Acid SCHEMBL8962476 0.81 L3MBTL1 (0.44) ESR1KCNH2NR3C1PGRNR3C2
SCHEMBL8053590 0.77 KMT2A (0.50) ESR1NR3C1PGRNR3C2ESR2
SCHEMBL9188703 0.76 NOS3 (0.53) ALDH1A1MAPTHSD17B10TDP1L3MBTL1
SCHEMBL30013065 0.76 NOS3 (0.53) ALDH1A1MAPTHSD17B10TDP1L3MBTL1
SCHEMBL5326602 0.76 NOS3 (0.53) ALDH1A1MAPTHSD17B10TDP1L3MBTL1
SCHEMBL34461657 0.76 NOS3 (0.53) ALDH1A1MAPTHSD17B10TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029542-A2 PRIMARY AMINES AS RENIN INHIBITORS Actelion Pharmaceuticals Ltd. (CH) 2009-03-04 EP claimed
WO-2007099509-A2 PRIMARY AMINES AS RENIN INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2007-09-07 WO claimed
EP-2029542-A2 PRIMARY AMINES AS RENIN INHIBITORS Actelion Pharmaceuticals Ltd. (CH) 2009-03-04 EP disclosed
WO-2007099509-A2 PRIMARY AMINES AS RENIN INHIBITORS ACTELION PHARMACEUTICALS LTD (CH) 2007-09-07 WO disclosed