Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 5/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.35 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921893 | 0.98 | NUDT1 (0.53) | NUDT1JAK2ACVR1USP30MAPK8 | |
| SCHEMBL3927139 | 0.98 | NUDT1 (0.53) | NUDT1JAK2ACVR1USP30MAPK8 | |
| Hydrochloric Acid SCHEMBL3926115 | 0.98 | NUDT1 (0.52) | NUDT1JAK2ACVR1USP30MAPK8 | |
| SCHEMBL3926811 | 0.97 | NUDT1 (0.52) | NUDT1JAK2ACVR1USP30MAPK8 | |
| SCHEMBL3922452 | 0.95 | NUDT1 (0.49) | NUDT1JAK2ACVR1USP30KDM4E | |
| SCHEMBL3932781 | 0.93 | NUDT1 (0.46) | NUDT1JAK2USP30MAPK8KDM4E | |
| SCHEMBL3922730 | 0.91 | NUDT1 (0.45) | NUDT1JAK2ACVR1USP30 | |
| SCHEMBL3924285 | 0.90 | JAK2 (0.44) | NUDT1JAK2ACVR1MAPK8KDM4E | |
| SCHEMBL3922760 | 0.90 | NUDT1 (0.43) | NUDT1JAK2ACVR1USP30IGF1R | |
| SCHEMBL3926953 | 0.90 | NUDT1 (0.43) | NUDT1ACVR1IGF1RCCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051980-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-02-26 | — | — | EP | disclosed |
| US-7531539-B2 | Pyrrolotriazine kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-05-12 | — | — | US | disclosed |
| EP-2051980-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008021924-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080045496-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045496-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | JAK2, NTRK2, NTRK3 | NUDT1 4271/4885JAK2 1/4885ACVR1 1835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.