SCHEMBL3921682

SCHEMBL3921682

O=C(/C=C/c1ccc(CNC(=O)c2ccc(N3CCCC3)cc2)cc1)NO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 12/20 1.00
HDAC3 O15379 12/20 1.00
HDAC8 Q9BY41 12/20 1.00
HDAC4 P56524 12/20 1.00
HDAC1 Q13547 12/20 1.00
HDAC2 Q92769 10/20 1.00
HDAC9 Q9UKV0 9/20 1.00
HDAC5 Q9UQL6 9/20 1.00
HDAC7 Q8WUI4 8/20 1.00
HDAC10 Q969S8 8/20 1.00
HDAC11 Q96DB2 8/20 1.00
PTGS2 P35354 1/20 0.53
CTSL P07711 2/20 0.52
CTSB P07858 2/20 0.52
MEF2D Q14814 2/20 0.51
MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3921684 1.00 HDAC6 (1.00) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL7259047 0.92 HDAC6 (0.84) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL3919380 0.85 HDAC6 (0.73) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL3919379 0.85 HDAC6 (0.73) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL3918069 0.83 HDAC1 (0.80) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL3918071 0.83 HDAC1 (0.80) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL3919573 0.81 HDAC6 (0.67) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL30598713 0.81 HDAC1 (0.73) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL3927969 0.80 HDAC1 (1.00) HDAC6HDAC3HDAC8HDAC4HDAC1
SCHEMBL3926505 0.80 HDAC1 (0.72) HDAC6HDAC3HDAC8HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025106604-A1 COMPOSITIONS AND METHODS RELATING TO ANTIVIRAL THERAPEUTICS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2025-05-22 WO claimed
US-12187698-B2 Crystalline forms of C21H22Cl2N4O2 BIOMED VALLEY DISCOVERIES, INC. (US) 2025-01-07 US claimed
US-20220324832-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 VERTEX PHARMACEUTICALS INCORPORATED 2022-10-13 US claimed
CN-114632159-A Antitumor composition and application thereof 澳门科技大学 2022-06-17 CN claimed
US-10813919-B2 Use of histone deacetylase inhibitors for enhancing immunotherapies INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2020-10-27 US claimed
US-20190030011-A1 USE OF HISTONE DEACETYLASE INHIBITORS FOR ENHANCING IMMUNOTHERAPIES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2019-01-31 US claimed
US-7495022-B2 α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors SK CHEMICALS CO., LTD. (KR) 2009-02-24 US claimed
US-20050124679-A1 Alpha, beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors SK CHEMICALS CO., LTD. (KR) 2005-06-09 US claimed
US-20260000714-A1 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN NON-HUMAN ANIMALS BIOMED VALLEY DISCOVERIES INC (US) 2026-01-01 US disclosed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 EP disclosed
EP-4653054-A2 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN HUMANS Biomed Valley Discoveries, Inc. (US) 2025-11-26 EP disclosed
US-12433920-B2 C. novyi for the treatment of solid tumors in non-human animals BIOMED VALLEY DISCOVERIES, INC. (US) 2025-10-07 US disclosed
EP-4108248-B1 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN HUMANS BIOMED VALLEY DISCOVERIES INC (US) 2025-09-17 EP disclosed
WO-2025106604-A1 COMPOSITIONS AND METHODS RELATING TO ANTIVIRAL THERAPEUTICS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2025-05-22 WO disclosed
EP-3730146-B1 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN HUMANS BIOMED VALLEY DISCOVERIES INC (US) 2022-05-04 EP disclosed
US-10813919-B2 Use of histone deacetylase inhibitors for enhancing immunotherapies INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2020-10-27 US disclosed
US-20190030011-A1 USE OF HISTONE DEACETYLASE INHIBITORS FOR ENHANCING IMMUNOTHERAPIES INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2019-01-31 US disclosed
US-7495022-B2 α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors SK CHEMICALS CO., LTD. (KR) 2009-02-24 US disclosed
US-20050124679-A1 Alpha, beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors SK CHEMICALS CO., LTD. (KR) 2005-06-09 US disclosed
WO-2003087066-A1 α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS SK CHEMICALS, CO., LTD. (KR) 2003-10-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220324832-A1 CRYSTALLINE FORMS OF C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 HDAC6 777/4885HDAC3 2519/4885HDAC8 3157/4885
US-12433920-B2 C. novyi for the treatment of solid tumors in non-human animals MKI67, HCCS, NCF1 HDAC6 3067/4885HDAC3 3133/4885HDAC8 3258/4885
US-12187698-B2 Crystalline forms of C21H22Cl2N4O2 CYP2F1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CA4 HDAC6 777/4885HDAC3 2519/4885HDAC8 3157/4885
US-20260000714-A1 C. NOVYI FOR THE TREATMENT OF SOLID TUMORS IN NON-HUMAN ANIMALS KIT, CPA3, MKI67 HDAC6 3131/4885HDAC3 3272/4885HDAC8 2243/4885
US-20050124679-A1 Alpha, beta-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors HDAC1, HDAC5, HDAC9 HDAC6 10/4885HDAC3 8/4885HDAC8 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.