Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.44 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179997 | 0.87 | MEN1 (0.49) | FLT1FLT4KDRMRGPRX4ABL1 | |
| SCHEMBL2773888 | 0.84 | MRGPRX4 (0.43) | FLT1FLT4KDRMRGPRX4ABL1 | |
| SCHEMBL11520744 | 0.84 | CA12 (0.46) | MRGPRX4ABL1ARPDK2PDK4 | |
| SCHEMBL2333339 | 0.83 | ABL1 (0.46) | FLT1FLT4KDRABL1PDK2 | |
| SCHEMBL16956211 | 0.83 | ABL1 (0.46) | FLT1FLT4KDRABL1PDK2 | |
| SCHEMBL10411246 | 0.83 | ABL1 (0.46) | FLT1FLT4KDRABL1PDK2 | |
| SCHEMBL12670851 | 0.83 | FLT1 (0.45) | FLT1FLT4KDRMRGPRX4AR | |
| SCHEMBL14393267 | 0.83 | FLT1 (0.45) | FLT1FLT4KDRMRGPRX4AR | |
| SCHEMBL7992182 | 0.83 | CYP4F2 (0.48) | FLT1FLT4KDRCA12CA1 | |
| SCHEMBL409948 | 0.81 | MEN1 (0.50) | PDK2PDK4GPR27CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1391476-A | Vasopressin agonist formulation and process | AMERICAN CYANAMID CO (US) | 2003-01-15 | — | — | CN | claimed |
| CN-112955448-B | Aromatic ring or aromatic heterocyclic compound and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2023-02-03 | — | — | CN | disclosed |
| EP-3104702-B1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2022-08-10 | — | — | EP | disclosed |
| US-20220127258-A1 | AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | The National Institutes of Pharmaceutical R&D Co., Ltd. (CN) | 2022-04-28 | — | — | US | disclosed |
| EP-3919489-A1 | AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | The National Institutes of Pharmaceutical R&D Co., Ltd (CN) | 2021-12-08 | — | — | EP | disclosed |
| CN-112955448-A | Aromatic ring or aromatic heterocyclic compound and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2021-06-11 | — | — | CN | disclosed |
| WO-2020156241-A1 | AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2020-08-06 | — | — | WO | disclosed |
| CN-109563057-A | Sulfonamide compounds or its salt | 大鹏药品工业株式会社 | 2019-04-02 | — | — | CN | disclosed |
| CN-109071484-A | Molecule with desinsection effectiveness, and intermediate relevant to these molecules, composition and method | 美国陶氏益农公司 | 2018-12-21 | — | — | CN | disclosed |
| US-10112936-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-10-30 | — | — | US | disclosed |
| US-6194407-B1 | INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION | 2001-02-27 | — | — | US | disclosed |
| CN-1272111-A | Tricyclic vasopressin agonists | AMERICAN HOME PROD (US) | 2000-11-01 | — | — | CN | disclosed |
| CN-1272110-A | Tricyclic vasopressin agonists | AMERICAN HOME PROD (US) | 2000-11-01 | — | — | CN | disclosed |
| WO-2000046224-A2 | TRICYCLIC PYRIDINE N-OXIDES VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-10 | — | — | WO | disclosed |
| US-6090803-A | ANTIDIABETIC AGENTS; INCONTINENCE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-18 | — | — | US | disclosed |
| CN-1254335-A | Nicotinamide derivatives | PFIZER PROD INC (US) | 2000-05-24 | — | — | CN | disclosed |
| EP-1000059-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1999006403-A1 | TRICYCLIC VASOPRESSIN AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10112936-B2 | Five-membered heterocycles useful as serine protease inhibitors | F12, F11, F5 | FLT1 896/4885FLT4 899/4885KDR 2563/4885 |
| US-20220127258-A1 | AROMATIC RING OR HETEROAROMATIC RING COMPOUNDS, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | CYP46A1, NR1H4, CYP7A1 | FLT1 523/4885FLT4 873/4885KDR 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.