Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933938 | 0.85 | GRIN2B (0.41) | VCPUSP30CCNE2CCNA2CCNE1 | |
| SCHEMBL3924645 | 0.85 | CCNE2 (0.45) | VCPUSP30CCNE2CCNA2CCNE1 | |
| SCHEMBL3922547 | 0.85 | VCP (0.37) | VCPUSP30CCNE2CCNA2CCNE1 | |
| SCHEMBL3922542 | 0.83 | GRIN2B (0.40) | VCPUSP30GRIN2BDPP4 | |
| SCHEMBL3924760 | 0.79 | HRH4 (0.43) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL5948011 | 0.76 | CCNE1 (0.48) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL3935077 | 0.76 | MAP3K5 (0.41) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL3924389 | 0.76 | MAPK8 (0.40) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL3927808 | 0.74 | NPC1 (0.36) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL3924707 | 0.73 | MKNK1 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | claimed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | claimed |
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |