Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28131061 | 0.85 | CLK4 (0.57) | CLK4DYRK1ANR3C2CLK1NPC1 | |
| SCHEMBL3159168 | 0.83 | CLK4 (0.56) | CLK4DYRK1ANR3C2CLK1NPC1 | |
| SCHEMBL17393176 | 0.82 | CLK4 (0.54) | CLK4DYRK1ANR3C2CLK1NPC1 | |
| SCHEMBL8422251 | 0.80 | MEN1 (0.68) | CLK4DYRK1ACLK1NPC1RAB9A | |
| SCHEMBL436482 | 0.77 | CLK4 (0.55) | CLK4DYRK1ANR3C2CLK1KDM4E | |
| SCHEMBL439371 | 0.77 | CLK4 (0.66) | CLK4DYRK1ACLK1NPC1RAB9A | |
| SCHEMBL8224486 | 0.77 | CLK4 (0.54) | CLK4DYRK1ACLK1NPC1RAB9A | |
| SCHEMBL346269 | 0.76 | KMT2A (0.67) | CLK4DYRK1ACLK1NPC1RAB9A | |
| SCHEMBL27766207 | 0.75 | CLK4 (0.53) | CLK4DYRK1ANR3C2CLK1KMT2A | |
| SCHEMBL20840603 | 0.75 | NPC1 (0.51) | CLK4DYRK1ANPC1IGF1RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032562-A2 | SELECTIVE INHIBITORS OF ROCK PROTEIN KINASE AND USES THEREOF | Vertex Pharmaceuticals Incorporated (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007133622-A2 | SELECTIVE INHIBITORS OF ROCK PROTEIN KINASE AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-11-22 | — | — | WO | disclosed |