Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | NOS2 | P35228 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | CLK1 | P49759 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4574800 | 0.85 | SMN1; SMN2 (0.59) | MEN1KMT2APOLBNOS2ALDH1A1 | |
| SCHEMBL28131061 | 0.84 | CLK4 (0.57) | MEN1KMT2APOLBNOS2CLK1 | |
| SCHEMBL3159168 | 0.82 | CLK4 (0.56) | MEN1KMT2APOLBNOS2CLK1 | |
| SCHEMBL10986892 | 0.81 | POLB (1.00) | MEN1KMT2APOLBNOS2ALDH1A1 | |
| SCHEMBL8419134 | 0.81 | MEN1 (0.72) | MEN1KMT2APOLBNOS2ALDH1A1 | |
| SCHEMBL439371 | 0.81 | CLK4 (0.66) | MEN1KMT2AALDH1A1CLK1CLK4 | |
| SCHEMBL17393176 | 0.81 | CLK4 (0.54) | MEN1KMT2APOLBNOS2CLK1 | |
| SCHEMBL8224486 | 0.81 | CLK4 (0.54) | MEN1KMT2APOLBNOS2ALDH1A1 | |
| SCHEMBL3175243 | 0.81 | NOS2 (1.00) | MEN1KMT2APOLBNOS2ALDH1A1 | |
| SCHEMBL15830494 | 0.81 | NOS2 (0.76) | MEN1KMT2APOLBNOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494671-B1 | 1-(4-PIPERIDINYL)BENZIMIDAZOLONES AS HISTAMINE H3 ANTAGONISTS | SCHERING CORP (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | SCHERING CORPORATION | 2007-06-21 | — | — | US | disclosed |
| US-7220735-B2 | Benzimidazolone histamine H3 antagonists | SCHERING CORPORATION (US) | 2007-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142369-A1 | Combination of an H3 antagonist/inverse agonist and an appetite suppressant | CNR2, GPR119, GLP1R | MEN1 991/4885KMT2A 193/4885POLB 4772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.