Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3920145 | 0.92 | DPP4 (0.49) | DPP4DPP8SCN9AAKT1 | |
| SCHEMBL3928397 | 0.92 | DPP4 (0.45) | DPP4DPP8ENPP1SCN9A | |
| SCHEMBL4137706 | 0.85 | DPP4 (0.47) | DPP4DPP8ENPP1 | |
| SCHEMBL8221016 | 0.83 | DPP4 (0.43) | DPP4DPP8ENPP1 | |
| SCHEMBL3919096 | 0.73 | DPP4 (0.48) | DPP4DPP8ENPP1 | |
| SCHEMBL3922240 | 0.72 | DPP4 (0.34) | DPP4DPP8 | |
| SCHEMBL3923067 | 0.71 | DPP4 (0.48) | DPP4DPP8PRKDC | |
| SCHEMBL3923064 | 0.71 | DPP4 (0.48) | DPP4DPP8PRKDC | |
| SCHEMBL3920719 | 0.67 | DPP4 (0.58) | DPP4DPP8 | |
| SCHEMBL3920717 | 0.67 | DPP4 (0.58) | DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485641-B2 | Substituted 3-amino-pyrrolidino-4-lactams | PFIZER, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-20070299076-A1 | Substituted 3-Amino-Pyrrolidino-4-Lactams | PFIZER INC | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299076-A1 | Substituted 3-Amino-Pyrrolidino-4-Lactams | PRMT1, PRMT7, PRMT3 | DPP4 783/4885DPP8 1978/4885PRKDC 4027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.