Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL27750005 | 0.95 | ALDH1A1 (0.80) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Biphenyl SCHEMBL1579788 | 0.95 | ALDH1A1 (0.80) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Ammonia Solution, Strong SCHEMBL27529417 | 0.95 | ALDH1A1 (0.80) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Ammonia Solution, Strong SCHEMBL16004680 | 0.95 | ALDH1A1 (0.80) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Biphenyl SCHEMBL6278085 | 0.95 | ALDH1A1 (0.80) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Biphenyl SCHEMBL19245 | 0.95 | ALDH1A1 (0.80) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Biphenyl SCHEMBL8628717 | 0.91 | ALDH1A1 (0.73) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Biphenyl SCHEMBL7916980 | 0.91 | ALDH1A1 (0.73) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Biphenyl SCHEMBL410566 | 0.91 | ALDH1A1 (0.73) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 | |
| Biphenyl SCHEMBL2997707 | 0.91 | ALDH1A1 (0.89) | ALDH1A1SLC18A3HSD17B10HSD11B1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007259-A1 | PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-15 | — | — | WO | disclosed |
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | F. HOFFMAN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| EP-2011783-A1 | Process for the preparation of an indole derivative | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012311-A1 | PROCESS FOR THE PREPARATION OF INDOLE DERIVATIVES | IDO1, IDO2, TPH1 | ALDH1A1 263/4885SLC18A3 483/4885HSD17B10 753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.