SCHEMBL392471

SCHEMBL392471

CCCCC(CC)C(=O)OC(C)CO

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA2 P00918 7/20 0.59
CA1 P00915 4/20 0.59
MAPK1 P28482 2/20 0.50
FAAH O00519 1/20 0.41
ATM Q13315 2/20 0.40
GAA P10253 1/20 0.40
XBP1 P17861 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
ALDH1A1 P00352 1/20 0.39
TSHR P16473 2/20 0.38
CYP3A4 P08684 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
SLC1A3 P43003 1/20 0.36
SLC1A2 P43004 1/20 0.36
SLC1A1 P43005 1/20 0.36
MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7217652 0.89 CA2 (0.63) CA2CA1MAPK1FAAHATM
SCHEMBL23581684 0.89 CA2 (0.63) CA2CA1MAPK1FAAHATM
SCHEMBL246299 0.84 FAAH (0.59) CA2CA1MAPK1FAAHALDH1A1
SCHEMBL1834730 0.84 CA2 (0.58) CA2CA1MAPK1FAAHATM
SCHEMBL28627724 0.84 CA2 (0.58) CA2CA1MAPK1FAAHATM
SCHEMBL7223074 0.84 FAAH (0.59) CA2CA1MAPK1FAAHALDH1A1
SCHEMBL1377605 0.84 FAAH (0.59) CA2CA1MAPK1FAAHALDH1A1
SCHEMBL149487 0.84 CA2 (0.58) CA2CA1MAPK1FAAHATM
SCHEMBL27803012 0.84 FAAH (0.59) CA2CA1MAPK1FAAHALDH1A1
SCHEMBL4286403 0.84 CA2 (0.61) CA2CA1MAPK1FAAHATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10751337-B2 Preservative free ocular compositions and methods for using the same for treating dry eye disease and other eye disorders Ocugen, Inc. (US) 2020-08-25 US disclosed
EP-3569223-A1 METHODS AND COMPOSITIONS FOR SUSTAINED DELIVERY OF DRUGS Intratus, Inc. (US) 2019-11-20 EP disclosed
EP-2493474-B1 METHODS AND COMPOSITIONS FOR SUSTAINED DELIVERY OF DRUGS INTRATUS INC (US) 2019-09-04 EP disclosed
US-20180221278-A1 PRSUSTAINED RELEASE OPTHALMIC FORMUATION AND METHODS FOR USING THE SAME Ocugen, Inc. (US) 2018-08-09 US disclosed
US-20180153885-A1 PRESERVATIVE FREE OCULAR COMPOSITIONS AND METHODS FOR USING THE SAME FOR TREATING DRY EYE DISEASE AND OTHER EYE DISORDERS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2018-06-07 US disclosed
US-9877964-B2 Methods and compositions for treating dry eye disease and other eye disorders Ocugen, Inc. (US) 2018-01-30 US disclosed
EP-3261620-A1 METHODS AND COMPOSITIONS FOR TREATING DRY EYE DISEASE AND OTHER EYE DISORDERS The Board of Trustees of the University of Illionis (US) 2018-01-03 EP disclosed
US-20170189396-A1 METHODS AND COMPOSITIONS FOR TREATING DRY EYE DISEASE AND OTHER EYE DISORDERS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2017-07-06 US disclosed
US-9597328-B2 Methods and compositions for treating dry eye disease and other eye disorders Ocugen, Inc. (US) 2017-03-21 US disclosed
WO-2016138049-A1 METHODS AND COMPOSITIONS FOR TREATING DRY EYE DISEASE AND OTHER EYE DISORDERS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2016-09-01 WO disclosed
EP-2493475-A2 METHODS AND COSMETIC PREPARATIONS FOR THE SUSTAINED DELIVERY OF THERAPEUTIC AGENTS TO THE EYE Intratus, Inc. (US) 2012-09-05 EP disclosed
US-8101654-B2 Percutaneously absorptive ophthalmic preparation comprising olopatadine SENJU PHARMACEUTICAL CO., LTD. (JP) 2012-01-24 US disclosed
WO-2011053801-A2 METHODS AND COSMETIC PREPARATIONS FOR THE SUSTAINED DELIVERY OF THERAPEUTIC AGENTS TO THE EYE INTRATUS, INC. (US) 2011-05-05 WO disclosed
WO-2011053792-A2 METHODS AND COMPOSITIONS FOR SUSTAINED DELIVERY OF DRUGS INTRATUS, INC. (US) 2011-05-05 WO disclosed
US-20110104206-A1 METHODS AND COMPOSITIONS FOR SUSTAINED DELIVERY OF DRUGS INTRATUS, INC. 2011-05-05 US disclosed
US-20110104083-A1 METHODS AND COSMETIC PREPARATIONS FOR THE SUSTAINED DELIVERY OF THERAPEUTIC AGENTS TO THE EYE INTRATUS, INC. 2011-05-05 US disclosed
US-20090209632-A1 Percutaneously Absorptive Ophthalmic Preparation Comprising Olopatadine SENJU PHARMACEUTICAL CO., LTD. (JP) 2009-08-20 US disclosed
US-20090143359-A1 Percutaneously Absorptive Ophthalmic Preparation Comprising Epinastine SENJU PHARMACEUTICAL CO., LTD. (JP) 2009-06-04 US disclosed
EP-1901708-A1 PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING OLOPATADINE Senju Pharmaceutical Co., Ltd. (JP) 2008-03-26 EP disclosed
WO-2007007863-A1 PERCUTANEOUSLY ABSORPTIVE OPHTHALMIC PREPARATION COMPRISING OLOPATADINE SENJU PHARMACEUTICAL CO., LTD. (JP) 2007-01-18 WO disclosed