Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | CNR2 | P34972 | 1/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960052 | 1.00 | CA12 (0.71) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL25547142 | 0.91 | CA12 (0.83) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL17827613 | 0.85 | CA12 (0.73) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL29019309 | 0.84 | ALDH1A1 (0.84) | L3MBTL1ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL28836818 | 0.83 | CA1 (0.73) | CA12CYP3A4CA9ALDH1A1CYP19A1 | |
| SCHEMBL27950177 | 0.83 | CA12 (0.71) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL5960116 | 0.83 | MEN1 (0.73) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL28113725 | 0.83 | CA12 (0.73) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL20946457 | 0.83 | CYP19A1 (0.69) | CA12CYP1A2CYP3A4ATMCA9 | |
| SCHEMBL26154030 | 0.83 | CA12 (0.71) | CA12CYP1A2CYP3A4ATMCA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035372-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008005338-A1 | MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |