Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 16/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MPL | P40238 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928049 | 0.90 | CHEK2 (0.84) | CHEK2 | |
| SCHEMBL3569187 | 0.90 | CHEK2 (0.66) | CHEK2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL3567770 | 0.90 | CHEK2 (0.66) | CHEK2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL3919712 | 0.87 | CHEK2 (0.67) | CHEK2 | |
| SCHEMBL3916748 | 0.87 | CHEK2 (0.82) | CHEK2 | |
| SCHEMBL3926681 | 0.87 | CHEK2 (0.81) | CHEK2 | |
| SCHEMBL3917925 | 0.86 | CHEK2 (0.68) | CHEK2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL7993467 | 0.86 | MPL (0.61) | CHEK2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL5189120 | 0.85 | CHEK2 (0.69) | CHEK2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL3917341 | 0.85 | CHEK2 (0.67) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | claimed |
| US-7504414-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20080009493-A1 | Substituted Benzimidazoles and Imidazo-[4,5]-Pyridines | ARIENTI KRISTEN L | 2008-01-10 | — | — | US | disclosed |
| US-7271261-B2 | Substituted benzimidazoles and imidazo-[4,5]-pyridines | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009493-A1 | Substituted Benzimidazoles and Imidazo-[4,5]-Pyridines | CDKN1A, DDB1, TMBIM6 | CHEK2 14/4885HDAC3 1336/4885HDAC1 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.