Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13584139 | 0.86 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL13585003 | 0.84 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| SCHEMBL17887852 | 0.82 | EPHX1 (0.62) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| SCHEMBL3998822 | 0.82 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2HDAC2HDAC8 | |
| SCHEMBL3916719 | 0.82 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| SCHEMBL10594051 | 0.82 | LMNA (0.62) | NPC1RAB9ASMN1; SMN2HDAC2HDAC8 | |
| SCHEMBL850447 | 0.82 | TAAR1 (0.55) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| SCHEMBL13825511 | 0.79 | SMN1; SMN2 (0.52) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| Phenformin SCHEMBL12487086 | 0.79 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| Phenformin SCHEMBL8424 | 0.79 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3911372-A1 | COMPOUND TARGETING NOREPINEPHRINE TRANSPORTER | Guangzhou Miphere Medical Technology Co., Ltd. (CN) | 2021-11-24 | — | — | EP | disclosed |
| WO-2020148154-A1 | COMPOUND TARGETING NOREPINEPHRINE TRANSPORTER | JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG (DE) | 2020-07-23 | — | — | WO | disclosed |
| US-7534418-B2 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-19 | — | — | US | disclosed |
| US-20060127309-A1 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060127309-A1 | Imaging agents | MPI, NPC1, NPC1L1 | NPC1 2/4885RAB9A 1900/4885SMN1; SMN2 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.