Phenformin

Phenformin

SCHEMBL8424

N=C(N)NC(=N)NCCc1ccccc1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.52
RAB9A P51151 4/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
LMNA P02545 3/20 0.50
TAAR1 Q96RJ0 2/20 0.50
GAA P10253 2/20 0.50
CA12 O43570 3/20 0.47
CA2 P00918 3/20 0.47
CA9 Q16790 3/20 0.47
CA1 P00915 2/20 0.47
ALDH1A1 P00352 4/20 0.47
IDO1 P14902 2/20 0.47
MAOA P21397 2/20 0.47
MAOB P27338 2/20 0.47
CYP3A4 P08684 2/20 0.47
KDM1A O60341 1/20 0.47
CYP1A2 P05177 1/20 0.47
HTR1A P08908 1/20 0.47
ADRA2A P08913 1/20 0.47
CYP2C8 P10632 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenformin SCHEMBL12487086 1.00 NPC1 (0.52) NPC1RAB9ASMN1; SMN2LMNATAAR1
Phenformin SCHEMBL15669213 0.98 NPC1 (0.50) NPC1RAB9ASMN1; SMN2LMNATAAR1
Phenformin SCHEMBL1560339 0.98 RAB9A (0.50) NPC1RAB9ASMN1; SMN2LMNATAAR1
Phenformin SCHEMBL210008 0.98 NPC1 (0.50) NPC1RAB9ASMN1; SMN2LMNATAAR1
Phenformin SCHEMBL3487197 0.98 NPC1 (0.50) NPC1RAB9ASMN1; SMN2LMNATAAR1
SCHEMBL18624768 0.97 NPC1 (0.49) NPC1RAB9ASMN1; SMN2LMNATAAR1
Phenformin SCHEMBL28415756 0.92 ALDH1A1 (0.57) NPC1RAB9ASMN1; SMN2LMNATAAR1
SCHEMBL7838315 0.90 L3MBTL1 (0.51) NPC1RAB9ATAAR1GAACYP2D6
Phenformin SCHEMBL11691594 0.89 MEN1 (0.47) NPC1RAB9ASMN1; SMN2TAAR1CA12
Phenformin SCHEMBL11697477 0.89 MEN1 (0.47) NPC1RAB9ASMN1; SMN2TAAR1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 19751 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122079768-A Method for selectively and efficiently depolymerizing and recycling PET in waste blended fabric 2026-05-26 CN claimed
EP-4499765-B1 COMPOSITIONS AND METHODS FOR TUNGSTEN ETCHING INHIBITION BASF SE (DE) 2026-05-06 EP claimed
EP-3956809-B1 IMAGE PROCESSING METHOD FOR AN IDENTITY DOCUMENT SURYS (FR) 2026-05-06 EP claimed
US-12605354-B2 Azelaic acid esters in the treatment or prevention of dyslipidemia and associated conditions NEW FRONTIER LABS, LLC (US) 2026-04-21 US claimed
US-20260076969-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2026-03-19 US claimed
EP-4243366-B1 NETWORK MONITORING AND TROUBLESHOOTING USING AUGMENTED REALITY JUNIPER NETWORKS INC (US) 2026-02-25 EP claimed
EP-4103445-B1 SYSTEM AND METHOD FOR RAIL SCANNING USING ELECTROMAGNETIC ENGINES HYPERLOOP TECH INC (US) 2026-02-18 EP claimed
US-20260028334-A1 N-(3-(BENZO[B]THIOPHENE-2-CARBOXAMIDO)-PHENYL)-2,3-DIHYDROBENZO[B][1,4]DIOXINE-6-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS LACTATE/ATP PRODUCTION INHIBITORS FOR THE TREATMENT OF CANCER WMT AG (DE) 2026-01-29 US claimed
EP-4684799-A2 ANTIBODIES THAT DISRUPT THE INTERACTION OF GAL3 AND INSULIN RECEPTOR OR INTEGRINS AND METHODS OF USE THEREOF TrueBinding, Inc. (US) 2026-01-28 EP claimed
US-20250360215-A1 PHARMACEUTICAL COMBINATIONS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE DISEASES YUH CHIOU HWA (US) 2025-11-27 US claimed
EP-0004770-B1 PHARMACEUTICAL AND DIETARY COMPOSITION COMPRISING GAMMA-LINOLENIC ACIDS EFAMOL LIMITED (GB) 1984-06-13 EP claimed
EP-0078434-A1 Pharmaceutical and dietary compositions EFAMOL LIMITED (GB) 1983-05-11 EP claimed
US-4346709-A Drug delivery devices comprising erodible polymer and erosion rate modifier ALZA CORPORATION (US) 1982-08-31 US claimed
US-4309415-A LINOLENIC ACID OR DERIVATIVE WITH MATERIAL WHICH ENHANCES BIOSYNTHESIS OF THROMBOXANE A2 VERRONMAY LIMITED (GB) 1982-01-05 US claimed
EP-0037175-A1 Pharmaceutical compositions EFAMOL LIMITED (GB) 1981-10-07 EP claimed
EP-0035856-A2 Pharmaceutical and dietary compositions EFAMOL LIMITED (GB) 1981-09-16 EP claimed
US-4254109-A INHIBIT LENS ALDOSE REDUCTASE AYERST, MCKENNA & HARRISON INC. (CA) 1981-03-03 US claimed
US-4254108-A ALDOSE REDUCTASE INHIBITORS AYERST, MCKENNA & HARRISON INC. (CA) 1981-03-03 US claimed
EP-0019423-A1 Pharmaceutical and dietary composition comprising gamma-linolenic acids EFAMOL LIMITED (GB) 1980-11-26 EP claimed
EP-0004770-A2 Pharmaceutical and dietary composition comprising gamma-linolenic acids EFAMOL LIMITED (GB) 1979-10-17 EP claimed