Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928779 | 0.95 | CHRNA7 (0.62) | MAOBCHRNA7HRH3SLC6A4MEN1 | |
| SCHEMBL12777929 | 0.86 | MAOB (0.68) | MAOBCHRNA7HRH3KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL27615790 | 0.86 | MAOB (0.57) | MAOBCHRNA7HRH3SLC6A4MEN1 | |
| SCHEMBL3919877 | 0.85 | CHRNA7 (0.62) | MAOBCHRNA7HRH3SLC6A4MEN1 | |
| SCHEMBL8163040 | 0.84 | POLB (0.69) | CHRNA7HRH3MEN1KMT2ALMNA | |
| SCHEMBL23709723 | 0.83 | ALDH1A1 (0.76) | MAOBCHRNA7HRH3SLC6A4MEN1 | |
| SCHEMBL3918199 | 0.82 | CHRNA7 (0.59) | MAOBCHRNA7HRH3SLC6A4MEN1 | |
| SCHEMBL21940834 | 0.82 | CHRNA7 (0.66) | MAOBCHRNA7HRH3MEN1KMT2A | |
| SCHEMBL1447408 | 0.81 | HRH3 (0.71) | MAOBCHRNA7HRH3MEN1KMT2A | |
| SCHEMBL3916814 | 0.80 | HRH3 (0.60) | CHRNA7HRH3SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511807-A | Substituted benzamide modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-19 | — | — | CN | claimed |
| EP-2038269-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-25 | — | — | EP | claimed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | claimed |
| WO-2008002816-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | WO | claimed |
| CN-101511807-A | Substituted benzamide modulators of the histamine H3 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-19 | — | — | CN | disclosed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | disclosed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | disclosed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | disclosed |
| WO-2008002816-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH2 | MAOB 743/4885CHRNA7 410/4885HRH3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.