Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926523 | 0.95 | MAOB (0.60) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1447408 | 0.88 | HRH3 (0.71) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3915425 | 0.87 | CHRNA7 (0.68) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3926220 | 0.84 | CHRNA7 (0.65) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5119237 | 0.82 | CHRNA7 (0.62) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL12777929 | 0.82 | MAOB (0.68) | CHRNA7KMT2AALDH1A1HRH3MAOB | |
| Hydrochloric Acid SCHEMBL27615790 | 0.82 | MAOB (0.57) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL3919877 | 0.81 | CHRNA7 (0.62) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL15624886 | 0.80 | CHRNA7 (0.94) | CHRNA7MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6633015 | 0.80 | CHRNA7 (0.70) | CHRNA7MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038269-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-25 | — | — | EP | claimed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | claimed |
| WO-2008002816-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | WO | claimed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | disclosed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | disclosed |
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-21 | — | — | US | disclosed |
| WO-2008002816-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045507-A1 | SUBSTITUTED BENZAMIDE MODULATORS OF THE HISTAMINE H3 RECEPTOR | HRH3, HRH4, HRH2 | CHRNA7 410/4885MEN1 2916/4885KMT2A 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.