Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19583040 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL17723467 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL1536103 | 0.93 | ALDH1A1 (0.47) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL2342461 | 0.93 | ALDH1A1 (0.47) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL1536115 | 0.93 | ALDH1A1 (0.47) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL1536102 | 0.93 | ALDH1A1 (0.47) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL31630375 | 0.93 | ALDH1A1 (0.47) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL22821135 | 0.90 | ALDH1A1 (0.46) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL16590857 | 0.90 | ALDH1A1 (0.46) | ALDH1A1HPGDNPSR1MAPTHSD17B10 | |
| SCHEMBL1543697 | 0.86 | TSHR (0.47) | ALDH1A1HPGDUSP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598281-B2 | Arylcycloakyl-substituted alkanoic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-10-06 | — | — | US | disclosed |
| US-7598281-B2 | Arylcycloakyl-substituted alkanoic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-10-06 | — | — | US | disclosed |
| US-7598281-B2 | Arylcycloakyl-substituted alkanoic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) ligands for the treatment of hyperlipidemia and diabetes | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-10-06 | — | — | US | disclosed |
| EP-1789403-B1 | N-(PHENYL-OXAZOL-4-YLMETHOXYMETHYL)-CYCLOHEXYL.SUCCINIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS WHICH ARE USED AS PPAR-LIGANDS (PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS) FOR THE TREATMENT OF HYPERLIPIDAEMIE AND DIABETES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-03-25 | — | — | EP | disclosed |
| EP-1789403-B1 | N-(PHENYL-OXAZOL-4-YLMETHOXYMETHYL)-CYCLOHEXYL.SUCCINIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS WHICH ARE USED AS PPAR-LIGANDS (PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS) FOR THE TREATMENT OF HYPERLIPIDAEMIE AND DIABETES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-03-25 | — | — | EP | disclosed |
| US-20070197605-A1 | ARYLCYCLOAKYL-SUBSTITUTED ALKANOIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-23 | — | — | US | disclosed |
| US-20070197605-A1 | ARYLCYCLOAKYL-SUBSTITUTED ALKANOIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-23 | — | — | US | disclosed |
| US-20070197605-A1 | ARYLCYCLOAKYL-SUBSTITUTED ALKANOIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197605-A1 | ARYLCYCLOAKYL-SUBSTITUTED ALKANOIC ACID DERIVATIVES USEFUL AS PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) LIGANDS FOR THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES | PPARA, PPARG, GPR119 | ALDH1A1 284/4885HPGD 1501/4885NPSR1 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.