SCHEMBL3928178

SCHEMBL3928178

CC(CCCCc1ccccc1)C(N)=O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTB4R Q15722 3/20 0.52
TSHR P16473 1/20 0.50
KMT2A Q03164 2/20 0.49
TRPA1 O75762 1/20 0.49
ALDH1A1 P00352 1/20 0.49
HPGD P15428 1/20 0.49
CYP2D6 P10635 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
LMNA P02545 2/20 0.49
MAPT P10636 1/20 0.49
RXFP1 Q9HBX9 1/20 0.49
FAAH O00519 1/20 0.48
S1PR2 O95136 1/20 0.48
S1PR4 O95977 1/20 0.48
S1PR1 P21453 1/20 0.48
S1PR3 Q99500 1/20 0.48
PKM P14618 1/20 0.48
HDAC3 O15379 1/20 0.47
MAPK1 P28482 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7598869 0.95 TSHR (0.51) LTB4RTSHRKMT2AALDH1A1HPGD
SCHEMBL8761 0.87 TSHR (0.64) TSHRKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL17403338 0.87 TSHR (0.64) TSHRKMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL7385392 0.86 LTB4R (0.66) LTB4RTSHRKMT2ATRPA1ALDH1A1
SCHEMBL17027841 0.84 LTB4R (0.68) LTB4RTSHRKMT2ATRPA1ALDH1A1
SCHEMBL17027837 0.84 LTB4R (0.68) LTB4RTSHRKMT2ATRPA1ALDH1A1
SCHEMBL6971015 0.84 LTB4R (0.68) LTB4RTSHRKMT2ATRPA1ALDH1A1
SCHEMBL6344592 0.84 LTB4R (0.68) LTB4RTSHRKMT2ATRPA1ALDH1A1
SCHEMBL11837264 0.81 LTB4R (0.54) LTB4RTSHRKMT2ATRPA1ALDH1A1
SCHEMBL28012282 0.81 LTB4R (0.58) LTB4RTSHRKMT2ATRPA1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038267-A2 THIADIAZOLIDINONE INHIBITORS OF PTPASE Novartis AG (CH) 2009-03-25 EP disclosed
WO-2007115058-A2 THIADIAZOLIDINONE INHIBITORS OF PTPASE NOVARTIS AG (CH) 2007-10-11 WO disclosed
EP-1254114-A2 MELANOCORTIN RECEPTOR AGONISTS AND ANTAGONISTS Melacure Therapeutics AB (SE) 2002-11-06 EP disclosed
WO-2001055106-A2 NOVEL MELANOCORTIN RECEPTOR AGONISTS AND ANTAGONISTS MELACURE THERAPEUTICS AB (SE) 2001-08-02 WO disclosed