Thioguanosine

Thioguanosine

SCHEMBL3928265

Nc1nc(S)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1.O=P(O)(O)OP(=O)(O)O

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.62
SLC29A1 Q99808 5/20 0.61
ADORA3 P0DMS8 2/20 0.61
ADORA1 P30542 1/20 0.61
PGK1 P00558 1/20 0.59
PGK2 P07205 1/20 0.59
NT5E P21589 3/20 0.58
LMNA P02545 1/20 0.56
HIF1A Q16665 1/20 0.56
ADORA2A P29274 3/20 0.56
ADORA2B P29275 2/20 0.56
P2RY2 P41231 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thioguanosine SCHEMBL3861782 0.94 CYP2C19 (0.67) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL3294897 0.94 CYP2C19 (0.67) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL8185769 0.91 CYP2C19 (0.73) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL4083505 0.91 CYP2C19 (0.73) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL608145 0.91 CYP2C19 (0.73) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL23927999 0.91 CYP2C19 (0.73) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL6748957 0.91 CYP2C19 (0.73) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL8612570 0.90 CYP2C19 (0.72) CYP2C19SLC29A1ADORA3ADORA1PGK1
Thioguanosine SCHEMBL8612560 0.90 CYP2C19 (0.72) CYP2C19SLC29A1ADORA3ADORA1PGK1
6-Thioguanylic Acid SCHEMBL15833214 0.88 CA5A (0.69) ADORA1NT5EP2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7524851-B2 Diagnostic methods for therapeutic compounds and methods for monitoring azathioprine therapy ROBERT BOSCH GESELLSCHAFT FUR MEDIZINISCHE FORSCHUNG (RBMF) (DE) 2009-04-28 US claimed
EP-4720100-A1 MODIFIED VECTORS CSL Behring LLC (US) 2026-04-08 EP disclosed
US-20250354166-A1 LENTIVIRAL VECTORS USEFUL FOR THE TREATMENT OF DISEASE CSL BEHRING L L C (US) 2025-11-20 US disclosed
EP-3655534-B1 COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES CSL BEHRING GENE THERAPY INC (US) 2025-07-16 EP disclosed
US-20250213580-A1 Improved Thiopurine Formulation and Treatment Methods DOUGLAS PHARMACEUTICALS LTD (NZ) 2025-07-03 US disclosed
CN-120193018-A Method for modifying the specificity of non-coding RNA molecules for silencing gene expression in eukaryotic cells 热带生物科学英国有限公司 2025-06-24 CN disclosed
EP-4499105-A1 IMPROVED THIOPURINE FORMULATION AND TREATMENT METHODS Douglas Pharmaceuticals Limited (NZ) 2025-02-05 EP disclosed
CN-111448318-B Method for modifying the specificity of non-coding RNA molecules for silencing gene expression in eukaryotic cells 热带生物科学英国有限公司 2025-01-28 CN disclosed
US-20240423989-A1 NOVEL FORMULATION AND TREATMENT METHODS ProdrugXtend Pty Ltd (AU) 2024-12-26 US disclosed
WO-2024241281-A1 MODIFIED VECTORS CSL BEHRING L.L.C. (US) 2024-11-28 WO disclosed
EP-3655534-A1 COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES Calimmune, Inc. (US) 2020-05-27 EP disclosed
EP-3541392-A1 IN VIVO CHEMOSELECTION WITH LOW DOSE THIOGUANINE Calimmune Inc. (US) 2019-09-25 EP disclosed
US-20190269687-A1 In Vivo Chemoselection with Low Dose Thioguanine CALIMMUNE INC (US) 2019-09-05 US disclosed
US-20190256855-A9 COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES CALIMMUNE INC (US) 2019-08-22 US disclosed
US-20190100759-A1 COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES CALIMMUNE INC (US) 2019-04-04 US disclosed
WO-2019058253-A1 MODIFYING THE SPECIFICITY OF NON-CODING RNA MOLECULES FOR SILENCING GENE EXPRESSION IN EUKARYOTIC CELLS Tropic Biosciences UK Limited (GB) 2019-03-28 WO disclosed
WO-2019018383-A1 COMPOSITIONS AND METHODS FOR TREATING BETA-HEMOGLOBINOPATHIES Calimmune, Inc. (US) 2019-01-24 WO disclosed
US-20180235972-A1 NOVEL FORMULATION AND TREATMENT METHODS ProdrugXtend Pty Ltd (AU) 2018-08-23 US disclosed
WO-2018094126-A1 IN VIVO CHEMOSELECTION WITH LOW DOSE THIOGUANINE Calimmune, Inc. (US) 2018-05-24 WO disclosed
US-20180140606-A1 In Vivo Chemoselection with Low Dose Thioguanine CALIMMUNE INC (US) 2018-05-24 US disclosed