Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27683032 | 0.88 | FLT3 (0.53) | FLT3KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL3923816 | 0.87 | PDGFRB (0.50) | FLT3MEN1KMT2APDGFRBPDGFRA | |
| SCHEMBL3924098 | 0.87 | FLT3 (0.47) | FLT3KDM4EALDH1A1HPGD | |
| SCHEMBL3935363 | 0.86 | MEN1 (0.47) | FLT3MEN1RAB9AKMT2A | |
| SCHEMBL3924069 | 0.78 | GRIN1 (0.48) | GRIN1GRIN2BKDM4EPDGFRBPDGFRA | |
| Hydrochloric Acid SCHEMBL3926589 | 0.76 | GRIN1 (0.52) | GRIN1GRIN2BKDM4EALDH1A1MAPT | |
| SCHEMBL27682863 | 0.75 | FLT3 (0.46) | FLT3KDM4EALDH1A1HPGD | |
| SCHEMBL27663289 | 0.75 | MEN1 (0.46) | FLT3MEN1RAB9AKMT2APDGFRB | |
| SCHEMBL5211901 | 0.75 | KMT2A (0.42) | FLT3MEN1RAB9AKMT2A | |
| SCHEMBL6661201 | 0.72 | FLT3 (0.58) | FLT3KDM4EALDH1A1MEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773770-B1 | INDOLE-2-CARBOXAMIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON NYRT (HU) | 2009-04-01 | — | — | EP | claimed |
| US-20090048303-A1 | Indole-2-carboxamidine derivatives as nmda receptor antago | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2009-02-19 | — | — | US | claimed |
| EP-1773770-A1 | INDOLE-2-CARBOXAMIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | Richter Gedeon Vegy Szeti Gy R Rt. (HU) | 2007-04-18 | — | — | EP | claimed |
| WO-2006010965-A1 | INDOLE-2 -CARBOXAMIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2006-02-02 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048303-A1 | Indole-2-carboxamidine derivatives as nmda receptor antago | GRIN3A, GRIN1, GRIN2C | FLT3 483/4885GRIN1 2/4885GRIN2B 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.