Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657213 | 0.93 | FLT3 (0.54) | FLT3DRD3DRD2KDM4EMTNR1A | |
| SCHEMBL6664487 | 0.90 | KDM4E (0.55) | FLT3KDM4EMTNR1AMTNR1BMEN1 | |
| SCHEMBL6657806 | 0.90 | DRD2 (0.54) | FLT3DRD3DRD2KDM4EMTNR1A | |
| SCHEMBL6661461 | 0.88 | ROCK2 (0.59) | FLT3DRD3DRD2KDM4EMTNR1A | |
| SCHEMBL6657726 | 0.86 | GAA (0.53) | DRD3DRD2KDM4EMTNR1AMTNR1B | |
| SCHEMBL6656183 | 0.86 | MTNR1A (0.57) | FLT3DRD3DRD2KDM4EMTNR1A | |
| SCHEMBL6657486 | 0.86 | MTNR1A (0.57) | FLT3DRD3DRD2KDM4EMTNR1A | |
| SCHEMBL3928684 | 0.85 | FLT3 (0.52) | FLT3DRD3DRD2KDM4EMTNR1A | |
| SCHEMBL13596219 | 0.82 | ADRB2 (0.63) | KDM4EMEN1KMT2AALDH1A1GAA | |
| SCHEMBL18669175 | 0.82 | KDM4E (0.60) | DRD3DRD2KDM4EHTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1460064-A1 | Indole-2-carboxamide derivatives useful as beta-2 agonists | Pfizer Limited (GB) | 2004-09-22 | — | — | EP | disclosed |
| EP-1440966-A1 | Indole derivatives useful for the treatment of diseases | Pfizer Limited (GB) | 2004-07-28 | — | — | EP | disclosed |