Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 8/20 | 0.46 |
| ▸ | CA2 | P00918 | 8/20 | 0.46 |
| ▸ | CA12 | O43570 | 4/20 | 0.46 |
| ▸ | CA9 | Q16790 | 4/20 | 0.46 |
| ▸ | CA4 | P22748 | 3/20 | 0.46 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21616621 | 0.81 | PSIP1 (0.50) | SMN1; SMN2GAAPDCD1CD274CA1 | |
| SCHEMBL21165417 | 0.79 | CA2 (0.62) | SMN1; SMN2GAACA1CA2CA12 | |
| SCHEMBL28039061 | 0.79 | CA2 (0.64) | SMN1; SMN2GAACA1CA2CA12 | |
| SCHEMBL1859957 | 0.78 | CA1 (0.62) | NAMPTSMN1; SMN2GAACA1CA2 | |
| SCHEMBL15699779 | 0.78 | SMN1; SMN2 (0.57) | NAMPTSMN1; SMN2GAACA1CA2 | |
| SCHEMBL1625535 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2GAAPDCD1CD274MAOA | |
| SCHEMBL8029246 | 0.76 | CHRM2 (0.51) | SMN1; SMN2PDCD1CD274CA1CA2 | |
| SCHEMBL24285412 | 0.76 | CA1 (0.44) | NAMPTSMN1; SMN2GAACA1CA2 | |
| SCHEMBL568013 | 0.76 | SMN1; SMN2 (0.50) | NAMPTSMN1; SMN2GAACA1CA2 | |
| SCHEMBL1751928 | 0.75 | SMN1; SMN2 (0.53) | NAMPTSMN1; SMN2GAACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797074-A4 | COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF IIII | ASTRAZENECA AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| EP-1797074-A1 | COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF IIII | AstraZeneca AB (SE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006033627-A1 | COMPOUNDS, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF IIII | ASTRAZENECA AB (SE) | 2006-03-30 | — | — | WO | disclosed |