Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | TET3 | O43151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.42 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.42 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1002235 | 0.82 | SLC6A2 (0.52) | SLC6A4SLC6A3SLC6A2P2RX7KMT2A | |
| SCHEMBL3932199 | 0.81 | SLC6A4 (0.57) | SLC6A4SLC6A3P2RX7TET3KMT2A | |
| SCHEMBL13540014 | 0.81 | SLC6A3 (0.69) | SLC6A4SLC6A3SLC6A2P2RX7MCHR1 | |
| SCHEMBL21680269 | 0.80 | EPHX2 (0.52) | P2RX7TET3KMT2AFBXL19CXXC5 | |
| SCHEMBL28077722 | 0.79 | KMT2A (0.43) | P2RX7TET3KMT2AFBXL19CXXC5 | |
| SCHEMBL9270769 | 0.77 | SLC6A4 (0.90) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL8233353 | 0.76 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL2229509 | 0.74 | MEN1 (0.62) | KMT2ADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL3518052 | 0.74 | SLC6A4 (0.97) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL5089821 | 0.74 | SLC6A4 (0.72) | SLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043655-A2 | PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS | Astex Therapeutics Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007125321-A2 | PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |