Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | AKT2 | P31751 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TET3 | O43151 | 1/20 | 0.45 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.45 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.45 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23002585 | 0.86 | MAOA (0.61) | SLC6A4SLC6A3KMT2ATET3FBXL19 | |
| SCHEMBL21680269 | 0.84 | EPHX2 (0.52) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL28077722 | 0.82 | KMT2A (0.43) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL3929243 | 0.81 | SLC6A4 (0.60) | SLC6A4SLC6A3KMT2ATET3FBXL19 | |
| SCHEMBL14386232 | 0.81 | SLC6A4 (0.49) | SLC6A4SLC6A3AKT2GSK3BHSD11B1 | |
| SCHEMBL1003431 | 0.80 | MEN1 (0.52) | SLC6A4SLC6A3KMT2AMEN1 | |
| SCHEMBL3910930 | 0.78 | SLC6A4 (0.61) | SLC6A4SLC6A3EPHX2 | |
| SCHEMBL1672926 | 0.78 | SLC6A3 (0.81) | SLC6A4SLC6A3MAOAMAOBTAAR1 | |
| SCHEMBL5166600 | 0.78 | SLC6A4 (0.64) | SLC6A4SLC6A3AKT2GSK3BMAOA | |
| SCHEMBL21078007 | 0.78 | SLC6A3 (0.64) | SLC6A4SLC6A3AKT2GSK3BMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421471-B1 | PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LTD (GB) | 2021-05-26 | — | — | EP | disclosed |
| EP-2043655-A2 | PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS | Astex Therapeutics Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007125321-A2 | PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-11-08 | — | — | WO | disclosed |