SCHEMBL3929375

SCHEMBL3929375

CC(C)COC(=O)N1CCC(Oc2cccc3c2CCN3c2ccc(S(C)(=O)=O)cc2F)CC1

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.81
CYP2C9 P11712 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3937727 0.90 GPR119 (1.00) GPR119CYP2C9
SCHEMBL3938260 0.88 GPR119 (0.79) GPR119CYP2C9
SCHEMBL3933425 0.87 GPR119 (0.80) GPR119CYP2C9
SCHEMBL3930850 0.84 GPR119 (0.61) GPR119CYP2C9
SCHEMBL4488416 0.83 GPR119 (1.00) GPR119CYP2C9
SCHEMBL3938347 0.82 GPR119 (0.58) GPR119CYP2C9
SCHEMBL3929615 0.78 GPR119 (0.67) GPR119CYP2C9
SCHEMBL3929937 0.77 GPR119 (0.61) GPR119
SCHEMBL4102858 0.77 GPR119 (0.60) GPR119
SCHEMBL3486645 0.77 GPR119 (0.61) GPR119CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2043744-A2 CHEMICAL COMPOUNDS SmithKline Beecham Corporation (US) 2009-04-08 EP claimed
WO-2008008887-A2 GPR119 AGONISTS FOR TREATING METABOLIC DISORDERS SMITHKLINE BEECHAM CORPORATION (US) 2008-01-17 WO claimed