Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3938041 | 0.90 | GPR119 (0.68) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3938345 | 0.86 | GPR119 (0.76) | GPR119 | |
| SCHEMBL3929375 | 0.82 | GPR119 (0.81) | GPR119CYP2C9 | |
| SCHEMBL3486645 | 0.76 | GPR119 (0.61) | GPR119CYP2C9KCNH2 | |
| SCHEMBL3925483 | 0.76 | GPR119 (0.55) | GPR119 | |
| SCHEMBL3930276 | 0.75 | GPR119 (0.54) | GPR119 | |
| SCHEMBL3941387 | 0.74 | GPR119 (0.61) | GPR119 | |
| SCHEMBL4488416 | 0.73 | GPR119 (1.00) | GPR119CYP2C9 | |
| SCHEMBL3938260 | 0.72 | GPR119 (0.79) | GPR119CYP2C9 | |
| SCHEMBL2333104 | 0.71 | GPR119 (0.77) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043744-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008008895-A1 | GPR119 AGONISTS FOR THE TREATMENT OF DIABETES AND RELATED DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008008887-A2 | GPR119 AGONISTS FOR TREATING METABOLIC DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-17 | — | — | WO | disclosed |