Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14177816 | 0.90 | TSHR (0.45) | KDM4ETSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL682587 | 0.84 | USP2 (0.49) | KDM4ESMN1; SMN2ALDH1A1HSD17B10HPGD | |
| SCHEMBL23164498 | 0.81 | KDM4E (0.41) | KDM4ETSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL16318734 | 0.80 | TXNRD1 (0.43) | KDM4ETSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL25439022 | 0.80 | NPSR1 (0.41) | KDM4EHSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL7422768 | 0.79 | CAPN1 (0.40) | SMN1; SMN2ALDH1A1HSD17B10HTTEGFR | |
| SCHEMBL3655249 | 0.77 | USP2 (0.35) | KDM4EALDH1A1LMNAMAPTHTT | |
| Hydrochloric Acid SCHEMBL7322104 | 0.76 | NR4A1 (0.40) | KDM4ETSHRALDH1A1HSD17B10LMNA | |
| SCHEMBL15554369 | 0.76 | KDM4E (0.40) | KDM4ETSHRSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL6105714 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |
| EP-0673247-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS. | MERCK & CO INC (US) | 1996-05-01 | — | — | EP | disclosed |
| EP-0673247-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1995-09-27 | — | — | EP | disclosed |