Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.38 |
| ▸ | TERT | O14746 | 7/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933480 | 0.85 | PAOX (0.44) | PAOXAPOBEC3AAPOBEC3GLMNAALDH1A1 | |
| SCHEMBL27854645 | 0.78 | PAOX (0.41) | PAOXTERTAPOBEC3AAPOBEC3GKMT2A | |
| SCHEMBL105467 | 0.76 | KDM5A (0.48) | PAOXKMT2AMEN1TSHRLMNA | |
| SCHEMBL5255803 | 0.76 | PAOX (0.39) | PAOXTERTAPOBEC3AAPOBEC3GKMT2A | |
| SCHEMBL2178380 | 0.76 | PAOX (0.53) | PAOXTERTAPOBEC3AAPOBEC3GKMT2A | |
| SCHEMBL8204357 | 0.74 | KDM5A (0.47) | PAOXKMT2AMEN1TSHRLMNA | |
| SCHEMBL177594 | 0.74 | NPSR1 (0.39) | PAOXTERTAPOBEC3AAPOBEC3GKMT2A | |
| SCHEMBL21422281 | 0.74 | PAOX (0.38) | PAOXTERTAPOBEC3AAPOBEC3GKMT2A | |
| SCHEMBL4459209 | 0.74 | TSHR (0.50) | PAOXTERTAPOBEC3AAPOBEC3GKMT2A | |
| SCHEMBL12086307 | 0.74 | TDP1 (0.45) | PAOXTERTAPOBEC3AAPOBEC3GKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060166982-A1 | Isotopically labelly indlinone derivatives and process for their preparation | PFIZER ITALIA S.R.L. (IT) | 2006-07-27 | — | — | US | claimed |
| EP-1542734-A1 | ISOTOPICALLY LABELLED INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Pharmacia Italia S.p.A. (IT) | 2005-06-22 | — | — | EP | claimed |
| WO-2004012776-A1 | ISOTOPICALLY LABELLED INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA ITALIA S.P.A. (IT) | 2004-02-12 | — | — | WO | claimed |
| US-9493402-B2 | Omega-aminoalkylamides of R-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2016-11-15 | — | — | US | disclosed |
| EP-1366018-B1 | OMEGA-AMINOALKYLAMIDES OF (R)-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS | DOMPÉ FARMACEUTICI S P A (IT) | 2016-07-06 | — | — | EP | disclosed |
| US-20130079514-A1 | \"OMEGA-AMINOALKYLAMIDES OF R-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS\ | Dompé S.p.A. (IT) | 2013-03-28 | — | — | US | disclosed |
| US-8288368-B2 | inhibitors of the C5a induced chemotaxis; psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, rheumatoid arthritis and in the prevention and the treatment of injury caused by ischemia and reperfusion | DOMPÉ PHA.R.MA S.P.A. (IT) | 2012-10-16 | — | — | US | disclosed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| US-20080045522-A1 | OMEGA-AMINOALKYLAMIDES OF R-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS | DOMPE PHA.R.MA S.P.A. (IT) | 2008-02-21 | — | — | US | disclosed |
| US-20060166982-A1 | Isotopically labelly indlinone derivatives and process for their preparation | PFIZER ITALIA S.R.L. (IT) | 2006-07-27 | — | — | US | disclosed |
| EP-1542734-A1 | ISOTOPICALLY LABELLED INDOLINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Pharmacia Italia S.p.A. (IT) | 2005-06-22 | — | — | EP | disclosed |
| US-5457105-A | anticancer use; e.g. 4-(3'-chloro-4'-fluoroanilino)-6,7-dimethoxyquinazoline (gefitinib) | ZENECA LIMITED (GB) | 1995-10-10 | — | — | US | disclosed |
| EP-0620491-A1 | Heat developable color light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |
| EP-0620490-A1 | Silver halide light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |
| EP-0566226-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1993-10-20 | — | — | EP | disclosed |
| US-5151357-A | Light sensitive elements with phosphonate groups | FUJI PHOTO FILM CO., LTD. (JP) | 1992-09-29 | — | — | US | disclosed |
| US-5075208-A | Releasing a photographically useful compound upon reduction | FUJI PHOTO FILM CO., LTD. (JP) | 1991-12-24 | — | — | US | disclosed |
| EP-0426112-A1 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1991-05-08 | — | — | EP | disclosed |
| US-4994363-A | Silver halide light-sensitive material containing a compound releasing a photographically useful group | FUJI PHOTO FILM CO., LTD. (JP) | 1991-02-19 | — | — | US | disclosed |
| US-4840887-A | USEFUL GROUP RELEASED BY CLEAVAGE BETWEEN SULFONYL GROUP AND A NITROGEN, SULFUR OR OXYGEN ATOM; STABILITY | FUJI PHOTO FILM CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166982-A1 | Isotopically labelly indlinone derivatives and process for their preparation | CYP3A5, SLC10A2, TMEM14C | PAOX 3722/4885TERT 4158/4885APOBEC3A 1840/4885 |
| US-20130079514-A1 | \"OMEGA-AMINOALKYLAMIDES OF R-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS\ | C5AR2, C3AR1, C5AR1 | PAOX 1287/4885TERT 894/4885APOBEC3A 781/4885 |
| US-20080045522-A1 | OMEGA-AMINOALKYLAMIDES OF R-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS | C5AR2, C3AR1, C5AR1 | PAOX 342/4885TERT 1628/4885APOBEC3A 1823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.