Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929947 | 0.85 | PAOX (0.38) | PAOXAPOBEC3AAPOBEC3GALDH1A1GAA | |
| SCHEMBL1147864 | 0.80 | PAOX (0.47) | PAOXAPOBEC3AAPOBEC3GALDH1A1NPSR1 | |
| SCHEMBL5512786 | 0.79 | PAOX (0.40) | PAOXAPOBEC3AAPOBEC3GALDH1A1NPSR1 | |
| SCHEMBL177754 | 0.78 | NPSR1 (0.47) | PAOXAPOBEC3AAPOBEC3GALDH1A1NPSR1 | |
| SCHEMBL149151 | 0.78 | AKR1B1 (0.50) | PAOXALDH1A1KDM5AKDM4CLMNA | |
| SCHEMBL164414 | 0.78 | PAOX (0.66) | PAOXAPOBEC3AAPOBEC3GALDH1A1NPSR1 | |
| SCHEMBL21422282 | 0.76 | APOBEC3A (0.47) | PAOXAPOBEC3AAPOBEC3GALDH1A1NPSR1 | |
| SCHEMBL21391387 | 0.76 | PAOX (0.44) | PAOXAPOBEC3AAPOBEC3GALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL9078509 | 0.76 | KDM5A (0.49) | PAOXALDH1A1KDM5AKDM4CLMNA | |
| SCHEMBL25529753 | 0.76 | ALDH1A1 (0.54) | PAOXAPOBEC3AAPOBEC3GALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |