Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13614548 | 0.88 | CRHR1 (0.57) | CRHR1CRHR2 | |
| SCHEMBL3925850 | 0.86 | CRHR1 (0.50) | CRHR1CRHR2PI4KBMEN1ALDH1A1 | |
| SCHEMBL3925857 | 0.86 | CRHR1 (0.50) | CRHR1CRHR2PI4KBMEN1ALDH1A1 | |
| SCHEMBL3930691 | 0.86 | CRHR1 (0.50) | CRHR1CRHR2PI4KBMEN1ALDH1A1 | |
| SCHEMBL3926510 | 0.86 | CRHR1 (0.53) | CRHR1CRHR2PI4KBACHE | |
| SCHEMBL3926829 | 0.86 | CRHR1 (0.55) | CRHR1CRHR2PI4KB | |
| SCHEMBL3932532 | 0.85 | CRHR1 (0.54) | CRHR1CRHR2MKNK1 | |
| SCHEMBL3925880 | 0.84 | CRHR1 (0.58) | CRHR1CRHR2 | |
| SCHEMBL3935105 | 0.84 | CRHR1 (0.53) | CRHR1CRHR2ALDH1A1LMNAHPGD | |
| SCHEMBL3926385 | 0.83 | CRHR1 (0.57) | CRHR1CRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869049-B1 | IMIDAZOPYRIDAZINE COMPOUNDS | LILLY CO ELI (US) | 2009-03-04 | — | — | EP | disclosed |