Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 10/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930691 | 1.00 | CRHR1 (0.50) | CRHR1CRHR2HPGDHSD17B10HTT | |
| SCHEMBL3925857 | 1.00 | CRHR1 (0.50) | CRHR1CRHR2HPGDHSD17B10HTT | |
| SCHEMBL3930746 | 0.86 | CRHR1 (0.52) | CRHR1CRHR2HPGDALDH1A1LMNA | |
| SCHEMBL13614548 | 0.82 | CRHR1 (0.57) | CRHR1CRHR2ALOX15 | |
| SCHEMBL3926510 | 0.81 | CRHR1 (0.53) | CRHR1CRHR2PI4KB | |
| SCHEMBL3926829 | 0.80 | CRHR1 (0.55) | CRHR1CRHR2PI4KB | |
| SCHEMBL3932532 | 0.80 | CRHR1 (0.54) | CRHR1CRHR2 | |
| SCHEMBL3932242 | 0.79 | CRHR1 (0.56) | CRHR1CRHR2LMNANPSR1 | |
| SCHEMBL3925880 | 0.79 | CRHR1 (0.58) | CRHR1CRHR2NFKB1NFKB2RELA | |
| SCHEMBL3935105 | 0.79 | CRHR1 (0.53) | CRHR1CRHR2HPGDHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869049-B1 | IMIDAZOPYRIDAZINE COMPOUNDS | LILLY CO ELI (US) | 2009-03-04 | — | — | EP | disclosed |