Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 14/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936294 | 0.90 | P2RY12 (0.59) | P2RY12CYP3A4CHRM2CYP2C9DRD3 | |
| SCHEMBL3941792 | 0.82 | P2RY12 (0.58) | P2RY12CYP3A4CHRM2CYP2C9DRD3 | |
| SCHEMBL4354445 | 0.79 | P2RY12 (0.56) | P2RY12CYP3A4CHRM2CYP2C9DRD3 | |
| SCHEMBL3930910 | 0.77 | P2RY12 (0.57) | P2RY12CYP3A4CHRM2CYP2C9DRD3 | |
| SCHEMBL4173356 | 0.73 | P2RY12 (0.69) | P2RY12CYP3A4CHRM2CYP2C9DRD3 | |
| SCHEMBL4365314 | 0.71 | P2RY12 (0.64) | P2RY12ALDH1A1 | |
| SCHEMBL4356065 | 0.70 | ALDH1A1 (0.55) | P2RY12CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL3930016 | 0.70 | KDM4E (0.59) | P2RY12ALDH1A1 | |
| SCHEMBL5054380 | 0.69 | P2RY12 (0.61) | P2RY12CYP3A4CHRM2CYP2C9DRD3 | |
| SCHEMBL3929451 | 0.68 | P2RY12 (0.60) | P2RY12CYP3A4CHRM2CYP2C9DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044024-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008004943-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |