Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | P2RY12 | Q9H244 | 12/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934625 | 0.92 | ALDH1A1 (0.57) | ALDH1A1KDM4EMAPTHSD17B10P2RY12 | |
| SCHEMBL3936294 | 0.82 | P2RY12 (0.59) | ALDH1A1KDM4EMAPTHSD17B10P2RY12 | |
| SCHEMBL3932119 | 0.81 | KDM4E (0.68) | ALDH1A1KDM4EMAPTHSD17B10P2RY12 | |
| SCHEMBL3600537 | 0.79 | P2RY12 (0.61) | ALDH1A1KDM4EP2RY12NPSR1CYP3A4 | |
| SCHEMBL3932387 | 0.78 | P2RY12 (0.66) | ALDH1A1KDM4EMAPTP2RY12 | |
| SCHEMBL3941792 | 0.74 | P2RY12 (0.58) | ALDH1A1KDM4EMAPTP2RY12CYP3A4 | |
| SCHEMBL5012431 | 0.74 | P2RY12 (0.54) | ALDH1A1KDM4EP2RY12NPSR1CYP3A4 | |
| SCHEMBL5141328 | 0.73 | P2RY12 (0.55) | ALDH1A1P2RY12CYP3A4CYP2C9 | |
| SCHEMBL3596659 | 0.71 | P2RY12 (0.81) | ALDH1A1P2RY12CYP3A4CYP2C9 | |
| SCHEMBL3586432 | 0.71 | P2RY12 (0.62) | ALDH1A1KDM4EP2RY12NPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286834-A1 | Pyridine Analogues VI | ASTRAZENECA AB (SE) | 2009-11-19 | — | — | US | disclosed |
| US-20080045494-A1 | Pyridine Analogues VI | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045494-A1 | Pyridine Analogues VI | P2RY12, P2RY6, P2RY11 | ALDH1A1 1604/4885KDM4E 2038/4885MAPT 4391/4885 |
| US-20090286834-A1 | Pyridine Analogues VI | P2RY12, P2RY6, P2RY11 | ALDH1A1 1888/4885KDM4E 3490/4885MAPT 3733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.