Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867307 | 0.89 | FFAR1 (0.55) | RXRARXRBRXRGFFAR1HDAC6 | |
| SCHEMBL11656517 | 0.81 | HDAC3 (0.53) | RXRARXRBRXRGFFAR1SMN1; SMN2 | |
| SCHEMBL7206139 | 0.79 | SMN1; SMN2 (0.47) | RXRARXRBRXRGFFAR1SMN1; SMN2 | |
| SCHEMBL15270538 | 0.79 | TSHR (0.50) | FFAR1SMN1; SMN2MAPK1HDAC3ADRA1A | |
| SCHEMBL9655945 | 0.79 | FFAR1 (0.45) | FFAR1SMN1; SMN2MAPK1HDAC3ADRA1A | |
| SCHEMBL3937280 | 0.79 | FFAR1 (0.45) | RXRARXRBRXRGFFAR1SMN1; SMN2 | |
| SCHEMBL3931150 | 0.79 | NPSR1 (0.44) | SMN1; SMN2MAPK1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL29594052 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2MAPK1HDAC1HDAC2ALDH1A1 | |
| SCHEMBL12984996 | 0.78 | L3MBTL1 (0.44) | L3MBTL1LMNATSHRNPC1PLAU | |
| SCHEMBL9656043 | 0.77 | TBXAS1 (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |
| WO-2009007418-A1 | NOVEL BRONCHODILATING ISOQUINOLINE AMIDES | RESPIRATORIUS AB (SE) | 2009-01-15 | — | — | WO | disclosed |