Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | STAT1 | P42224 | 2/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927929 | 0.93 | GAA (0.56) | ALDH1A1STAT1PTGDR2KDM4EPKM | |
| SCHEMBL3930627 | 0.93 | ALDH1A1 (0.55) | ALDH1A1STAT1PTGDR2KDM4ENAMPT | |
| SCHEMBL3929081 | 0.93 | ALDH1A1 (0.55) | ALDH1A1STAT1PTGDR2KDM4ENAMPT | |
| SCHEMBL3927533 | 0.91 | CYP3A4 (0.52) | ALDH1A1PTGDR2KDM4ENAMPTGAA | |
| SCHEMBL5745578 | 0.89 | KMT2A (0.57) | ALDH1A1PTGDR2KDM4ENAMPTPKM | |
| SCHEMBL3925079 | 0.86 | MEN1 (0.64) | ALDH1A1PTGDR2KDM4EGAAMEN1 | |
| SCHEMBL3936493 | 0.85 | PTGDR2 (0.50) | ALDH1A1STAT1PTGDR2KDM4ENAMPT | |
| SCHEMBL3928366 | 0.84 | PKM (0.51) | ALDH1A1STAT1KDM4EPKMGAA | |
| SCHEMBL3929258 | 0.84 | STAT1 (0.54) | ALDH1A1STAT1KDM4EPKMGAA | |
| SCHEMBL5795313 | 0.83 | MEN1 (0.69) | ALDH1A1KDM4EPKMGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | claimed |
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |