Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.71 |
| ▸ | NPC1 | O15118 | 5/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.58 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL96696 | 0.88 | RAB9A (0.68) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL21974272 | 0.84 | RAB9A (0.69) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL6324430 | 0.83 | MAPK1 (0.73) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL12866 | 0.83 | RAB9A (0.69) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL28957095 | 0.82 | RAB9A (0.68) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL96695 | 0.82 | RAB9A (0.68) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL1544640 | 0.82 | RAB9A (0.68) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL102445 | 0.82 | RAB9A (0.66) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL3938068 | 0.82 | RAB9A (0.50) | RAB9ATDP1NPC1MAPK1L3MBTL1 | |
| SCHEMBL19835591 | 0.81 | TDP1 (0.62) | RAB9ATDP1NPC1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2043644-A1 | NF- B INHIBITOR | Otsuka Pharmaceutical Co., Ltd. (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010601-A1 | NF- ϰB INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-01-24 | — | — | WO | disclosed |