Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL9 | O00512 | 9/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3941513 | 0.91 | SMN1; SMN2 (0.48) | BCL9CTNNB1HTTLMNAUSP2 | |
| SCHEMBL3942001 | 0.90 | MAPT (0.49) | BCL9CTNNB1ALDH1A1HTTLMNA | |
| SCHEMBL3941279 | 0.89 | BCL9 (0.46) | BCL9CTNNB1ATM | |
| SCHEMBL3928445 | 0.89 | BCL9 (0.47) | BCL9CTNNB1ALDH1A1NPSR1LMNA | |
| SCHEMBL3941453 | 0.88 | BCL9 (0.47) | BCL9CTNNB1ALDH1A1NPSR1NPC1 | |
| SCHEMBL3940272 | 0.88 | ALDH1A1 (0.50) | BCL9CTNNB1ALDH1A1HTTLMNA | |
| SCHEMBL3936472 | 0.87 | TP53 (0.48) | BCL9CTNNB1ALDH1A1NPSR1NPC1 | |
| SCHEMBL3935876 | 0.87 | BCL9 (0.50) | BCL9CTNNB1GAA | |
| SCHEMBL3935829 | 0.87 | NPC1 (0.53) | BCL9CTNNB1ALDH1A1NPSR1NPC1 | |
| SCHEMBL3933582 | 0.87 | GAA (0.49) | BCL9CTNNB1ALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |