Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BCL9 | O00512 | 2/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
| ▸ | USP5 | P45974 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940272 | 0.91 | ALDH1A1 (0.50) | ALDH1A1HTTLMNATSHRBCL9 | |
| SCHEMBL3941453 | 0.91 | BCL9 (0.47) | NPC1USP2ALDH1A1HTTLMNA | |
| SCHEMBL3940596 | 0.91 | MEN1 (0.53) | NPC1USP2ALDH1A1HTTLMNA | |
| SCHEMBL3941513 | 0.91 | SMN1; SMN2 (0.48) | USP2HTTLMNABCL9CTNNB1 | |
| SCHEMBL3933582 | 0.91 | GAA (0.49) | ALDH1A1HTTLMNATP53NPSR1 | |
| SCHEMBL3936472 | 0.91 | TP53 (0.48) | NPC1ALDH1A1HTTLMNATP53 | |
| SCHEMBL3928444 | 0.89 | BCL9 (0.55) | ALDH1A1LMNATP53BCL9CTNNB1 | |
| SCHEMBL3930533 | 0.88 | BCL9 (0.50) | ALDH1A1TSHRBCL9CTNNB1MEN1 | |
| SCHEMBL3939617 | 0.88 | KMT2A (0.45) | ALDH1A1LMNABCL9CTNNB1MEN1 | |
| SCHEMBL3932848 | 0.87 | BCL9 (0.47) | NPC1USP2ALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |