Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.44 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3281372 | 0.85 | KDM4E (0.48) | KDM4EALDH1A1CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL13463015 | 0.83 | EGLN1 (0.36) | KDM4EALDH1A1NPSR1HPGDEGLN1 | |
| SCHEMBL13938231 | 0.83 | KDM4E (0.47) | KDM4EALDH1A1NPSR1HPGDSTAT3 | |
| SCHEMBL2017928 | 0.83 | EGLN1 (0.58) | KDM4EALDH1A1NPSR1STAT3HIF1A | |
| SCHEMBL3580539 | 0.82 | NR4A2 (0.40) | KDM4EALDH1A1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL3575594 | 0.82 | NR4A2 (0.40) | KDM4EALDH1A1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL30745057 | 0.82 | LMNA (0.54) | KDM4EALDH1A1NPSR1HPGDEGLN1 | |
| SCHEMBL3580771 | 0.81 | PLA2G2A (0.42) | KDM4EALDH1A1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL3573811 | 0.81 | PLA2G2A (0.42) | KDM4EALDH1A1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL30745105 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1NPSR1HPGDSTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786807-B1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2009-07-29 | — | — | EP | disclosed |
| US-7479489-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2009-01-20 | — | — | US | disclosed |
| EP-1786807-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021340-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-03-02 | — | — | WO | disclosed |
| US-20060040927-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2006-02-23 | — | — | US | disclosed |
| US-5658933-A | Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040927-A1 | Heterocyclic antiviral compounds | HAVCR2, POLR1A, HCCS | KDM4E 2915/4885ALDH1A1 113/4885NPSR1 2185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.