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Sugi Predict / Compounds / SCHEMBL3933045

SCHEMBL3933045

SCHEMBL3933045

Cc1ccc(NC(=O)c2cccc(S(N)(=O)=O)c2)cc1C(=O)Nc1cccnc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 14/20 1.00
▸ CSF1R P07333 4/20 0.70
▸ MAPT P10636 1/20 0.65
▸ L3MBTL1 Q9Y468 1/20 0.61
▸ KIT P10721 1/20 0.60
▸ KDR P35968 1/20 0.60
▸ MAPK14 Q16539 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3933255 0.91 BRAF (1.00) BRAFCSF1RMAPTL3MBTL1KIT
SCHEMBL3937779 0.85 BRAF (1.00) BRAFCSF1RKITKDRMAPK14
SCHEMBL3942407 0.85 MEN1 (0.77) BRAFCSF1RMAPT
SCHEMBL3944742 0.85 BRAF (0.75) BRAFCSF1RMAPTL3MBTL1KIT
SCHEMBL3932800 0.85 BRAF (0.75) BRAFCSF1RMAPTL3MBTL1KIT
SCHEMBL3934972 0.84 BRAF (0.78) BRAFCSF1RMAPTKITKDR
SCHEMBL3934255 0.83 BRAF (0.83) BRAFCSF1RKITKDRMAPK14
SCHEMBL3942520 0.83 BRAF (1.00) BRAFCSF1RKITKDRMAPK14
SCHEMBL1276903 0.83 BRAF (1.00) BRAFCSF1R
SCHEMBL3945794 0.83 BRAF (0.80) BRAFCSF1RKITKDRMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1831198-B1 PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS ASTRAZENECA AB (SE) 2009-04-08 — — EP disclosed
CN-101128454-A Pyridine carboxamide derivatives for use as anticancer agents ASTRAZENECA AB (SE) 2008-02-20 — — CN disclosed