Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | BRAF | P15056 | 11/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.75 |
| ▸ | RECQL | P46063 | 1/20 | 0.75 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | CSF1R | P07333 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932223 | 0.92 | BRAF (0.71) | MEN1KMT2AALDH1A1LMNABRAF | |
| SCHEMBL3940456 | 0.88 | BRAF (0.63) | MEN1KMT2AALDH1A1LMNABRAF | |
| SCHEMBL1649391 | 0.87 | MEN1 (1.00) | MEN1KMT2AALDH1A1LMNAPOLB | |
| SCHEMBL3933255 | 0.86 | BRAF (1.00) | BRAFMAPTCSF1R | |
| SCHEMBL3933045 | 0.85 | BRAF (1.00) | BRAFMAPTCSF1R | |
| SCHEMBL3933251 | 0.84 | BRAF (0.64) | MEN1KMT2AALDH1A1LMNABRAF | |
| SCHEMBL3944742 | 0.82 | BRAF (0.75) | BRAFMAPTCSF1R | |
| SCHEMBL3937779 | 0.80 | BRAF (1.00) | BRAFCSF1R | |
| SCHEMBL3932800 | 0.80 | BRAF (0.75) | BRAFMAPTCSF1R | |
| SCHEMBL3934972 | 0.80 | BRAF (0.78) | BRAFMAPTCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |