Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 12/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 4/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929957 | 0.82 | CSF1R (0.78) | CSF1RMAPK14BRAF | |
| SCHEMBL1276893 | 0.80 | CSF1R (1.00) | CSF1RMAPK14MEN1KMT2ABRAF | |
| SCHEMBL1420016 | 0.79 | RAF1 (0.65) | CSF1RBRAFRAF1 | |
| SCHEMBL3933053 | 0.76 | SMN1; SMN2 (0.60) | CSF1RMAPK14SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3934404 | 0.75 | CSF1R (0.83) | CSF1RBRAF | |
| SCHEMBL3934946 | 0.74 | CSF1R (0.60) | CSF1RSMN1; SMN2MEN1KMT2ABRAF | |
| SCHEMBL13459839 | 0.74 | RAF1 (0.52) | CSF1RMAPK14SMN1; SMN2BRAFRAF1 | |
| SCHEMBL5487784 | 0.74 | CSF1R (0.55) | CSF1RBRAFRAF1 | |
| SCHEMBL22772386 | 0.74 | ABL1 (0.63) | CSF1RMAPK14BRAFRAF1 | |
| SCHEMBL3944484 | 0.74 | CSF1R (0.73) | CSF1RMAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |