Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723042 | 0.89 | GAA (0.51) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL6328621 | 0.87 | SMN1; SMN2 (0.59) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL19630439 | 0.87 | SMN1; SMN2 (0.59) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL2792543 | 0.85 | GAA (0.56) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL2792546 | 0.85 | GAA (0.56) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL6421334 | 0.80 | NPC1 (0.57) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL27943386 | 0.79 | GAA (0.56) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL17198268 | 0.79 | MEN1 (0.55) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL30716729 | 0.79 | ALDH1A1 (0.60) | GAACYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL3018141 | 0.79 | ALDH1A1 (0.60) | GAACYP1A2KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |