Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | BTK | Q06187 | 9/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | BLK | P51451 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934918 | 0.83 | CYP2C9 (0.56) | BRAFCYP2C9SMN1; SMN2 | |
| SCHEMBL2943817 | 0.82 | BLK (0.58) | BTKMAPK14BLKKITLCK | |
| SCHEMBL5815535 | 0.79 | BRAF (0.56) | BRAFCYP2C9BTKJAK2CSF1R | |
| SCHEMBL3932501 | 0.77 | BRAF (1.00) | BRAFCYP2C9BTKJAK2CSF1R | |
| SCHEMBL2943457 | 0.77 | LCK (0.54) | BRAFBTKJAK2MAPK14BLK | |
| SCHEMBL1367088 | 0.77 | BLK (0.45) | BTKBLKALDH1A1SMN1; SMN2KIT | |
| SCHEMBL1367703 | 0.77 | PIK3CA (0.60) | BRAFBTKBLKKIT | |
| SCHEMBL3943854 | 0.76 | BRAF (0.55) | BRAFBTKCSF1RBLKALDH1A1 | |
| SCHEMBL4019946 | 0.76 | KIT (0.59) | BRAFBTKCSF1RMAPK14BLK | |
| SCHEMBL24869675 | 0.76 | CYP2C9 (0.50) | BRAFCYP2C9JAK2CSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |