Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.56 |
| ▸ | BTK | Q06187 | 6/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | ULK1 | O75385 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3933265 | 0.79 | BRAF (0.61) | BRAFCYP2C9BTKMAPK14JAK2 | |
| SCHEMBL2943886 | 0.76 | BTK (0.76) | BTKMAPK14KITBLKLCK | |
| SCHEMBL2946275 | 0.74 | BTK (0.70) | BTKMAPK14KITBLKLCK | |
| SCHEMBL2948804 | 0.74 | BTK (0.68) | BTKMAPK14KITBLKLCK | |
| SCHEMBL1537904 | 0.72 | ULK1 (0.53) | ULK1LMNAGAASMN1; SMN2 | |
| SCHEMBL3932501 | 0.72 | BRAF (1.00) | BRAFCYP2C9BTKMAPK14JAK2 | |
| SCHEMBL3934918 | 0.72 | CYP2C9 (0.56) | BRAFCYP2C9LMNATP53GAA | |
| SCHEMBL29458485 | 0.70 | MALT1 (0.58) | MALT1LMNAGAASMN1; SMN2 | |
| SCHEMBL22644321 | 0.70 | MALT1 (0.58) | MALT1LMNAGAASMN1; SMN2 | |
| SCHEMBL3931460 | 0.70 | BRAF (0.71) | BRAFCYP2C9BTKMAPK14JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006067445-A2 | CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |