Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.59 |
| ▸ | KDR | P35968 | 2/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | BTK | Q06187 | 7/20 | 0.47 |
| ▸ | BLK | P51451 | 2/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943817 | 0.81 | BLK (0.58) | KITKDRMAPK14BTKBLK | |
| SCHEMBL3936114 | 0.81 | CYP1A2 (0.61) | KITKDRMAPK14BRAFKMT2A | |
| SCHEMBL18146767 | 0.77 | SMN1; SMN2 (0.51) | KITKMT2ABTKBLKNPC1 | |
| SCHEMBL3933265 | 0.76 | BRAF (0.61) | KITMAPK14BRAFBTKBLK | |
| SCHEMBL2943457 | 0.76 | LCK (0.54) | KITKDRMAPK14BRAFBTK | |
| SCHEMBL3934041 | 0.75 | BRAF (0.63) | KITKDRMAPK14BRAFKMT2A | |
| SCHEMBL28286247 | 0.75 | KMT2A (0.64) | KITKDRMAPK14KMT2ANPC1 | |
| SCHEMBL2950585 | 0.74 | KDR (1.00) | KITKDRMAPK14BRAFBTK | |
| SCHEMBL29657055 | 0.74 | PTK2 (0.62) | KMT2ARAB9APIK3CA | |
| SCHEMBL114189 | 0.74 | PTK2 (0.62) | KMT2ARAB9APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |